Dr. Donald O. Freytes, Ph.D.; Joint Department of Biomedical Engineering at UNC-CH and NCSU

Author: REdesign Lab (Page 2 of 5)

New Paper Accepted at Tissue Engineering, Part A

The members of the REdesign Lab are delighted to inform you of a new study, led by PhD candidate Emily W. Ozpinar and former undergraduate research assistant Ariana L. Frey, accepted at Tissue Engineering, Part A! Through a collaboration with the NCSU College of Veterinary Medicine,  our study explores the use of porcine-derived dermis extracellular matrix hydrogels as a substrate for mast cell viability and maturation. The project has been generously funded by the Comparative Medicine Institute’s Young Scholar Program (YSP) and Summer Interdisciplinary Research Initiative (SIRI), the UNC-CH/NCSU Joint Department of Biomedical Engineering’s Abrams Scholar Program and the NCSU Office of Undergraduate Research. We thank these funders for their support.

The citation is below:

Ozpinar EW*, Frey AL*, Arthur GK, Mora-Navarro C, Biehl A, Snider DB, Cruse G and Freytes DO. Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation. Tissue Engineering Part A. Published Online (October 2020).

*= Co-first authors

Congratulations to all the authors!

Andreea and Emily Awarded 2020 CMI FTE Scholarships

Congratulations to REdesign PhD candidates Andreea Badileanu and Emily W. Ozpinar for being awarded 2020 Associate Member Scholarships from the Functional Tissue Engineering (FTE) group of the Comparative Medicine Institute! These scholarships of $500 will support research and professional development in the upcoming academic year for Andreea and Emily. This funding was open to all graduate student and postdoctoral associate members of the CMI FTE group through an application process.

We thank the CMI FTE group for this funding.

Way to go, Andreea and Emily!

Paper accepted! “Fast Automated Approach for the Derivation of Acellular Extracellular Matrix (ECM) Scaffolds from Porcine Soft Tissues”

The REdesign Lab is very excited to announce that our most recent publication was accepted in the journal ACS Biomaterials Science & Engineering!

In this work, our lab members developed a new industry scalable tool to derive ECM scaffolds for hydrogel production from porcine heart and vocal fold tissues. The paper is in press and will soon be available online!

The main authors, Dr. Camilo Mora-Navarro and Andreea Badileanu have also worked with the Office of Research Commercialization at NC State to file a Provisional Patent Application (No. 63/024,870) for their invention titled: “Fast Automated Approach for the Derivation of Acellular Extracellular Matrix Scaffolds from Tissues.”

The process just started, but we are very excited about the newly developed system, which will propel  the automated production of ECM hydrogels forward.

Special thanks goes to Jenkins, Wilson, Taylor & Hunt, P.A., the REdesign lab members, and our funding sources: National Institutes of Health/National Institute on Deafness and Other Communication Disorders (R01DC017139, R01DC017743).

REdesign Lab 2019-2020 Abrams Scholars Finish and Present Their Research

Congratulations to the four Abrams Scholars from the REdesign Lab, who have completed their year of sponsored independent research. The Abrams Scholarship program in the UNC-CH/NCSU Joint Department of Biomedical Engineering (BME) provides stipends to top BME undergraduate student researchers to conduct independent research in BME and BME-affiliated labs. Their research culminates in May when the scholars deliver presentations to the BME department on their progress and findings. The 2019-2020 Abrams Scholars from the REdesign Lab and their presentation titles are as follows:

Amber DetwilerComparing Dermal Fibroblast Donor Age and Time in Culture for In Vitro Hydrogel-Based Skin Graft Modeling

Ariana FreyEngineering a Three-Dimensional In Vitro Platform for Mast Cell Maturation

Cody Helm – Engineering a Nanocarrier Drug Delivery Model to Target Mast Cells in an Extracellular Matrix Hydrogel

Isabel MayoMicrofabrication of a Heart-on-a-Chip Platform for High-Throughput Screening

We thank the Abrams Scholar program and the UNC-CH/NCSU Joint Department of Biomedical Engineering  for funding these great students throughout the 2019-2020 school year. Great work!

REdesign Undergrads Present at Spring 2020 NCSU Undergrad Research Symposium

Three REdesign Lab undergraduate researchers presented their work at the North Carolina State University (NCSU)’s 29th Annual Spring Undergraduate Research & Creativity Symposium! This spring, the symposium took place online, where undergraduate researchers across the University showcased their projects through a poster/video format.

The following REdesign Lab researchers presented:

Amber DetwilerComparing Dermal Fibroblast Donor Age and Time in Culture for In Vitro Hydrogel-Based Skin Graft Modeling

Ariana FreyEngineering a Three-Dimensional In Vitro Platform for Mast Cell Maturation

Cody Helm – Engineering a Nanocarrier Drug Delivery Model to Target Mast Cells in an Extracellular Matrix Hydrogel

Amber, Ariana and Cody are also Abrams Scholars through the BME department, previous Summer Interdisciplinary Research Initiative (SIRI) students through the Comparative Medicine Institute (CMI), and recipients of NCSU Office of Undergraduate Research (OUR) grants. We thank these generous programs for their funding.

Congratulations to another completed school year of productive research!

Collaboration with Cheng Lab Published in Science Translational Medicine

A paper as a result of a collaboration between the REdesign Lab and the Biotherapeutics Lab (PI: Dr. Ke Cheng) was published as the cover story in this week’s issue of Science Translational Medicine. Acellular cardiac patches were made from porcine heart extracellular matrix and synthetic cardiac stromal cells. These off-the-shelf patches were able to improve repair after myocardial infarction in rats and pigs.

NC State University featured this study in a recent news article.

Additionally, the study was featured in Nature Reviews Cardiology as a Research Highlight!

Citation is below:

Huang K, Ozpinar EW, Tang J, Shen D, Su T, Qiao L, Liang H, Mathews K, Scharf V, Freytes DO and Cheng K. An Off-the-Shelf Artificial Cardiac Patch Improves Cardiac Repair After Myocardial Infarction in Rats and Pigs. Sci. Transl. Med. 12, eaat9683 (2020).

Andreea Becomes Ph.D. Candidate

A big congratulations goes to  graduate student Andreea Badileanu, who passed her oral preliminary exam, becoming REdesign Lab’s newest PhD candidate! We all look forward to the great and innovative work she will conduct during her candidacy.

Way to go, Andreea!

New Paper Accepted at ACS Biomaterials Science & Engineering

The REdesign Lab is proud to start the year with a new paper acceptance at ACS Biomaterials Science & Engineering! Led by Dr. Camilo Mora-Navarro, the study debuts vocal fold lamina propria as a hydrogel and demonstrates its ability to modulate fibroblast activation via TGF-b1.  Our collaborators are from the New York University School of Medicine and the NCSU College of Veterinary Medicine.

The citation is below:

Mora Navarro CA, Badileanu A, Gracioso Martins AM, Ozpinar EW, Gaffney L, Huntress I, Harrell E, Enders JR, Peng X, Branski RC, and Freytes DO. Porcine Vocal Fold Lamina Propria-Derived Biomaterials Modulates TGF-b1 Mediated Fibroblast Activation In Vitro. ACS Biomaterials Science & Engineering. Accepted (January 2020).

Congratulations!

REdesign Lab Presents at TERMIS-AM

The REdesign Lab is back from the 2019 Tissue Engineering and Regenerative Medicine International Society (TERMIS)-Americas Chapter Annual Meeting in Orlando, FL! It was an event full of great scientific talks, networking opportunities, poster presentations and warm weather.

Dr. Camilo Mora-Navarro was selected to give an oral presentation in the Biobased Materials for Regenerative Medicine session. The title of his talk was “Decellularized Vocal Fold Lamina Propria-ECM and Associated Matrix-bound Vesicles: Proteomic and In Vitro Characterization Of The TGF-β1 Mediated Fibrotic Response In Human Fibroblasts”. Dr. Mora-Navarro was also selected as a Student Young Investigator Section (SYIS) Top 10 Oral Presentation at TERMIS!

The REdesign Lab had the following poster presentations (presenting author is underlined and in bold):

Andreea Badileanu In Vitro Co-culture Under Static And Vibratory Conditions To Study How Vocal Fold Lamina Propria Extracellular Matrix Hydrogel Modulates Macrophage Polarization And Fibroblast Activation

Lewis Gaffney Muscle And Tendon Derived Extracellular Matrix Promotes Expression Of MTJ Specific Integrins In Myoblast Cell Culture

Dr. Ana Gracioso MartinsA Cost-effective In Vitro Testing Platform Using Light-assisted Functional Characterization Of Engineered Heart Tissues

Emily Wrona OzpinarModulation of BMP Expression In Pluripotent Stem Cell-Derived Cardiomyocytes By Direct and Indirect Co-Cultures With Macrophages

Dr. Gracioso Martins, Andreea, Emily, Lewis, Dr. Freytes and Dr. Mora-Navarro at TERMIS-AM in Orlando, FL.

What a great event!

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