We are pleased to announce another paper acceptance. Amber Detwiler lead the study titled “Donor Age and Time in Culture Affect Dermal Fibroblast Contraction in an In Vitro Hydrogel Model” Amber started in our lab as a SIRI student working collaboratively with Kathryn Polkoff from Jorge Piedrahita’s Lab and Lewis Gaffney from our lab. Congrats to all of the author’s especially Amber D. for publishing her first paper as an undergraduate researcher!
Little is known about the impact of donor cell age and time in culture on the contraction of cellular, hydrogel-based skin grafts. These results show how cellular phenotypes of porcine fibroblasts differ based on donor age and time in culture. This information is beneficial when addressing important inconsistencies in biomanufacturing of bioengineered skin grafts and in vitro models. These findings are relevant to research and therapies using bioengineered skin graft models and the results can be used to increase reproducibility and consistency during the production of bioengineered skin constructs. The information from this study can be extrapolated to future in vivo studies using human dermal fibroblasts in an in vivo model to help determine the best donor age and time in culture for optimal wound healing outcomes or more reproducible in vitrotesting constructs.
Citation: Tissue Engineering Part A.ahead of printhttp://doi.org/10.1089/ten.tea.2021.0217
